Recombinant MTAP (Tumor Suppressor Marker) Antibody
Product Sizes
100 ug
£671.00
4507-MSM4-P1-100UG
About this Product
- SKU:
- 4507-MSM4-P1
- Additional Names:
- 5'-methylthioadenosine phosphorylase
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- rMTAP/1813
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 31kDa; which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine; which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene; p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates); whose mechanism of action; in part; involves this de novo purine pathway.
- Host:
- Mouse
- Immunogen:
- Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 31kDa
- Research Area:
- Cardiovascular; Cytokine Signaling; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=118264
