Myelin Protein Zero / MPZ Antibody
Product Sizes
100 ug
£671.00
4359-MSM2-P1ABX-100UG
About this Product
- SKU:
- 4359-MSM2-P1ABX
- Additional Names:
- Myelin peripheral protein | Myelin protein zero
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MPZ/7390
- Clonality:
- Monoclonal
- Extra Details:
- Zero; also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation; cause demyelinating neuropathies; and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation; which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain; abundant in thymus and most abundant in white matter of the CNS.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human MPZ protein
- Isotype:
- IgG2a
- Molecular Weight:
- 28kDa
- Research Area:
- Developmental Biology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=130813
