Microphthalmia Transcription Factor (MITF) Antibody
Product Sizes
20 ug
£364.00
4286-MSM2-P0-20UG
About this Product
- SKU:
- 4286-MSM2-P0
- Additional Names:
- Class E basic helix-loop-helix protein 32
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MITF/915
- Clonality:
- Monoclonal
- Extra Details:
- MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium; and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation; resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition; Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist; including MITF-A; MITF-B; MITF-C; MITF-H; and MITF-M; which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. This MAb recognizes a nuclear protein; which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes; benign nevi and dysplastic nevi.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human MiTF protein
- Isotype:
- IgG1
- Molecular Weight:
- 52-56kDa (doublet)
- Research Area:
- B Cell Markers; Cancer; Cardiovascular; Mast Cell Marker; Stem Cell Differentiation
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=117995
