Recombinant MGMT (Marker of Suppressor of Mutation and Carcinogenesis) Antibody
Product Sizes
100 ug
£671.00
4255-RBM11-P1-100UG
About this Product
- SKU:
- 4255-RBM11-P1
- Additional Names:
- 6-O-methylguanine-DNA methyltransferase | O-6-methylguanine-DNA-alkyltransferase
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- MGMT/8364R
- Clonality:
- Monoclonal
- Extra Details:
- Cancer chemotherapeutic alkylating agents (e.g. BCNU;) act by inducing formation of lethal cross√¢ ÔøΩ ÔøΩlinks at the O6√¢ ÔøΩ ÔøΩ alkylguanine position in DNA. MGMT transfers alkyl adducts from the O6√¢ ÔøΩ ÔøΩposition of guanine in DNA (prior to cross√¢ ÔøΩ ÔøΩlink formation) to a cysteine residue in its own sequence; thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA√¢ ÔøΩ ÔøΩdamage it can tolerate. In normal tissues; MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely to be drug resistant
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa1-100) of human MGMT (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 21.646 kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=130174
