MGMT (Marker of Suppressor of Mutation and Carcinogenesis) Antibody
Product Sizes
20 ug
£364.00
4255-MSM1-P0-20UG
About this Product
- SKU:
- 4255-MSM1-P0
- Additional Names:
- 6-O-methylguanine-DNA methyltransferase | O-6-methylguanine-DNA-alkyltransferase
- Application:
- Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- MGMT/4791
- Clonality:
- Monoclonal
- Extra Details:
- Cancer chemotherapeutic alkylating agents (e.g. BCNU;) act by inducing formation of lethal cross links at the O6 alkylguanine position in DNA. MGMT transfers alkyl adducts from the O6 position of guanine in DNA (prior to cross link formation) to a cysteine residue in its own sequence; thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA damage it can tolerate. In normal tissues; MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely to be drug resistant
- Host:
- Mouse
- Immunogen:
- Purified His-tagged MGMT protein
- Isotype:
- IgG1
- Molecular Weight:
- 21.646 kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=117932
