CD46 (Membrane Cofactor Protein) Antibody
Product Sizes
20 ug
£364.00
4179-MSM1-P0-20UG
About this Product
- SKU:
- 4179-MSM1-P0
- Additional Names:
- TLX | Trophoblast leukocyte common antigen
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- 122.2
- Clonality:
- Monoclonal
- Extra Details:
- CD46 acts as a cofactor for complement factor I; a serine protease; which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells; which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10; and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
- Host:
- Mouse
- Immunogen:
- Recombinant human CD46 protein
- Isotype:
- IgG1
- Molecular Weight:
- 56-66kDa
- Research Area:
- Complement System; Endothelial Cell Marker; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=117817
