MCM5 (Transcription Factor) Antibody
Product Sizes
100 ug
£671.00
4174-MSM1-P1ABX-100UG
About this Product
- SKU:
- 4174-MSM1-P1ABX
- Additional Names:
- DNA replication licensing factor MCM5 | CDC46 homolog | P1-CDC46 | MCM5 | CDC46
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- MCM5/3200
- Clonality:
- Monoclonal
- Extra Details:
- The mini-chromosome maintenance (MCM) family of proteins; including MCM2; MCM3; MCM4 (Cdc21); MCM5 (Cdc46); MCM6 (Mis5) and MCM7 (Cdc47); are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth; peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif; which is predicted to mediate ATP-dependent opening of double- stranded DNA. MCM proteins are regulated by E2F transcription factors; which induce MCM expression; and by protein kinases; which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3; which can be prevented by caspase inhibitors; results in the inactivation of the MCM complex (composed of at least MCM proteins 2-6) during apoptosis. A complex composed of MCM4; MCM6 and MCM7 has been shown to be involved in DNA helicase activity; and MCM5 is involved in IFN-γ-induced Stat1α transcription activation.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa500-734) of human MCM5 protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 90kDa
- Research Area:
- Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=150399
