MCM4 (Pan Cancer Marker) Antibody
Product Sizes
100 ug
£671.00
4173-MSM1-P1ABX-100UG
About this Product
- SKU:
- 4173-MSM1-P1ABX
- Additional Names:
- 19G antibody; AI325074 antibody; AU045576 antibody; CDC 21 antibody ;CDC 54 antibody; CDC21 antibody; CDC21 homolog antibody; CDC21; S. pombe; homolog of antibody; CDC54 antibody; Cell division cycle 21; S. pombe; homolog of antibody; DNA replication licensing factor MCM 4 antibody; DNA replication licensing factor MCM4 antibody; hCdc 21 antibody; hCdc21 antibody; Homolog of S. pombe cell devision cycle 21 antibody; KIAA4003 antibody; mcdc21 antibody ;MCM 4 antibody; MCM 4 minichromosome maintenance deficient 4 antibody; mcm4 antibody; MCM4 minichromosome maintenance deficient 4 antibody; MCM4 minichromosome maintenance deficient 4; mitotin (S. cerevisiae) antibody; MCM4_HUMAN antibody Mcmd4 antibody ;MGC33310 antibody; Minichromosome maintenance 4 antibody; Minichromosome maintenance complex component 4 antibody; Minichromosome maintenance deficient (S. cerevisiae) 4 antibody; Minichromosome maintenance deficient 4 antibody; Minichromosome maintenance deficient 4 homolog (S. cerevisiae) antibody; Minichromosome maintenance; S. cerevisiae; homolog of; 4 antibody; mKIAA4003 antibody; NKCD antibody NKGCD antibody; P1 CDC21 antibody; P1-CDC21 antibody; P1CDC21 antibody
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- MCM4/3041
- Clonality:
- Monoclonal
- Extra Details:
- The mini-chromosome maintenance (MCM) family of proteins; including MCM2; MCM3; MCM4 (Cdc21); MCM5 (Cdc46); MCM6 (Mis5) and MCM7 (Cdc47); are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth; peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif; which is predicted to mediate ATP-dependent opening of double- stranded DNA. MCM proteins are regulated by E2F transcription factors; which induce MCM expression; and by protein kinases; which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3; which can be prevented by caspase inhibitors; results in the inactivation of the MCM complex (composed of at least MCM proteins 2-6) during apoptosis. A complex composed of MCM4; MCM6 and MCM7 has been shown to be involved in DNA helicase activity; and MCM5 is involved in IFN-γ-induced Stat1α transcription activation.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa600-800) of human MCM4 protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 100kDa
- Research Area:
- Epigenetics
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=142996
