Myelin Basic Protein [p Thr98] (Marker of Oligodendrocytes & Myelin) Antibody
Product Sizes
100 ug
£671.00
4155-MSM6-P1ABX-100UG
About this Product
- SKU:
- 4155-MSM6-P1ABX
- Additional Names:
- Myelin A1 protein | Myelin membrane encephalitogenic protein
- Application:
- ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- MBP/4276
- Clonality:
- Monoclonal
- Extra Details:
- Myelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30% of the total protein and about 10% of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin; and has been called the executive molecule of myelin . MBP can interact with a number of polyanionic proteins including actin; tubulin; calmodulin; and clathrin; and negatively charged lipids; and acquires structure on binding to them. It may act as a membrane actin-binding protein; which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas. Phosphorylation been shown to decrease its ability to aggregate lipid vesicles and consequently destabilising the compact structure ofmyelin; a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. MBP/4276 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.
- Host:
- Mouse
- Immunogen:
- Synthetic peptide corresponding to human MBP when phosphorylated at threonine 98.
- Isotype:
- IgG2a
- Molecular Weight:
- 14-22kDa
- Research Area:
- Cardiovascular; Complement System; Developmental Biology; Neuroscience
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=117724
