Recombinant SMAD4 / DPC4 (Pancreatic Adenocarcinoma Marker / Tumor Suppressor) Antibody
Product Sizes
100 ug
£671.00
4089-RBM19-P1-100UG
About this Product
- SKU:
- 4089-RBM19-P1
- Additional Names:
- Deletion target in pancreatic carcinoma 4 | SMAD family member 4
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- SMAD/6309R
- Clonality:
- Monoclonal
- Extra Details:
- Signaling from the ligand-activated membrane receptor serine/threonine kinases to nuclear targets is mediated by a set of evolutionarily conserved proteins known as DPC4. Upon ligand binding; the receptors of the TGF-尾 family phosphorylate SMAD proteins (SMAD1 and SMAD2). These proteins then move into the nucleus; where they activate transcription. To carry out this function; the receptor activated SMAD1 and 2 require association with the product of deleted in pancreatic carcinoma; locus 4 (DPC4); also known as SMAD4. SMAD4/DPC4 is also implicated as a tumor suppressor; since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. The lack of SMAD4 expression is present in approximately 80% of cases of pancreatic adenocarcinoma; but rarely in endometrial (0%); colorectal (0%); ovarian (3%); lung (0%); breast (2%) adenocarcinomas; and malignant melanoma (4%). SMAD4is an important marker for confirming a diagnosis of pancreatic adenocarcinoma.
- Host:
- Rabbit
- Immunogen:
- Recombinant human full-length (aa1-552) SMAD4 protein
- Isotype:
- IgG
- Molecular Weight:
- 61kDa
- Research Area:
- Cardiovascular; Colon Cancer; Developmental Biology; Infectious Disease; Neuroinflammation; Nuclear Marker; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=117690
