Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Antibodies

Recombinant SMAD4 (Pancreatic Adenocarcinoma Marker) Antibody

Product Sizes
100 ug
£671.00
4089-MSM20-P1ABX-100UG
About this Product
SKU:
4089-MSM20-P1ABX
Additional Names:
Deletion target in pancreatic carcinoma 4 | SMAD family member 4
Application:
Immunohistochemistry
translate.label.attr.clone:
rSMAD4/6310
Clonality:
Monoclonal
Extra Details:
Signaling from the ligand-activated membrane receptor serine/threonine kinases to nuclear targets is mediated by a set of evolutionarily conserved proteins known as DPC4.Upon ligand binding; the receptors of the TGF-β family phosphorylate SMAD proteins (SMAD1 and SMAD2). These proteins then move into the nucleus; where they activate transcription. To carry out this function; the receptor activated SMAD1 and 2 require association with the product of deleted in pancreatic carcinoma; locus 4 (DPC4); also known as SMAD4. SMAD4/DPC4 is also implicated as a tumor suppressor; since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. The lack of SMAD4 expression is present in approximately 80% of cases of pancreatic adenocarcinoma; but rarely in endometrial (0%); colorectal (0%); ovarian (3%); lung (0%); breast (2%) adenocarcinomas; and malignant melanoma (4%). SMAD4is an important marker for confirming a diagnosis of pancreatic adenocarcinoma.
Host:
Mouse
Immunogen:
Amino acids 1-552 representing full-length human SMAD4
Isotype:
IgG1
Molecular Weight:
61kDa
Research Area:
Cardiovascular; Colon Cancer; Developmental Biology; Infectious Disease; Neuroinflammation; Nuclear Marker; Signal Transduction; Transcription Factors
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody