SMAD4 (Pancreatic Adenocarcinoma Marker) Antibody
Product Sizes
100 ug
£671.00
4089-MSM1X-P1ABX-100UG
About this Product
- SKU:
- 4089-MSM1X-P1ABX
- Additional Names:
- Deletion target in pancreatic carcinoma 4 | SMAD family member 4
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- SPM448
- Clonality:
- Monoclonal
- Extra Details:
- Signaling from the ligand-activated membrane receptor serine/threonine kinases to nuclear targets is mediated by a set of evolutionarily conserved proteins known as DPC4. Upon ligand binding; the receptors of the TGF-尾 family phosphorylate SMAD proteins (SMAD1 and SMAD2). These proteins then move into the nucleus; where they activate transcription. To carry out this function; the receptor activated SMAD1 and 2 require association with the product of deleted in pancreatic carcinoma; locus 4 (DPC4); also known as SMAD4. SMAD4/DPC4 is also implicated as a tumor suppressor; since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. SMAD4 is absent in approximately 80% of pancreatic adenocarcinoma; but rarely in endometrial; colorectal; ovarian; lung; breast adenocarcinomas; and malignant melanom. SMAD4 is an important marker for confirming a diagnosis of pancreatic adenocarcinoma. Patients with pancreatic adenocarcinomas with SMAD4 protein expression had significantly longer survival than SMAD4 negative patients.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human STAT6 protein
- Isotype:
- IgG2a
- Molecular Weight:
- 61kDa
- Research Area:
- Cardiovascular; Colon Cancer; Developmental Biology; Infectious Disease; Neuroinflammation; Nuclear Marker; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=117665
