CD205 / LY75 / DEC-205 Antibody
Product Sizes
100 ug
£671.00
4065-MSM1-P1-100UG
About this Product
- SKU:
- 4065-MSM1-P1
- Additional Names:
- C-type lectin domain family 13 member B | DEC-205 | gp200-MR6
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- CD205/3720
- Clonality:
- Monoclonal
- Extra Details:
- DEC-205 (LY75; lymphocyte antigen 75; GP200-MR6) is a 1;695 residue (mature form) multi-lectin receptor that belongs to the MMR (macrophage mannose receptor) family of multidomain molecules. MMR family molecules mediate membrane receptor targeting to endosomes or lysosomes rich in major histocompatibility complex class II (MHC II) products. Expressed in mature dendritic cells (DC); DEC-205 contains an extracellular N-terminal cysteine-rich domain; a fibronectin type II domain; ten C-type carbohydrate recognition domains; a single transmembrane region and a small cytoplasmic C-terminal domain (31 amino acids) containing a tyrosine at 1679. DEC-205 elicits either an agonistic or antagonistic effect on IL-4 function; which is demonstrated by the ability of DEC-205 to imitate IL-4-induced maturation of epithelium or to inhibit IL-4-induced proliferation of T cells; respectively. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1006-1130) of human LY75 protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 198kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=117481
