Lymphocyte Specific Protein 1 (LSP1) / pp52 Antibody
Product Sizes
100 ug
£671.00
4046-MSM2-P1ABX-100UG
About this Product
- SKU:
- 4046-MSM2-P1ABX
- Additional Names:
- 47 kDa actin-binding protein | 52 kDa phosphoprotein | Lymphocyte-specific antigen WP34
- Application:
- ELISA
- translate.label.attr.clone:
- LSP1/3042
- Clonality:
- Monoclonal
- Extra Details:
- LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding; leukocyte-specific (including B and T lymphocytes; granulocytes and macrophages); phosphoprotein. However; mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes; stromal cells and fibroblasts); suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5; which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA; tandem pairs of Ets and SP1 motifs; and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions; including cell motility and chemotaxis.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human LSP1 protein (around aa174-278) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 52kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=117453
