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Antibodies

CD91 / LDL Receptor Related Protein 1 (LRP1) Antibody

Product Sizes
100 ug
£671.00
4035-MSM1-P1-100UG
About this Product
SKU:
4035-MSM1-P1
Additional Names:
Alpha-2-macroglobulin receptor | Apolipoprotein E receptor
Application:
Immunohistochemistry
translate.label.attr.clone:
LRP1/6784
Clonality:
Monoclonal
Extra Details:
Members of the LDL receptor gene family; including LDLR (low density lipoprotein receptor); LEP1 (low density lipoprotein related protein); megalin (also designated GP330); VLDLR (very low density lipoprotein receptor) and apoER2 are characterized by a cluster of cysteine-rich class A repeats; epidermal growth factor (EGF)-like repeats; YWTD repeats and an O-linked sugar domain. LRP1; also designated LRP and α-2-Macroglobulin receptor; is an endocytic receptor that mediates the uptake of at least 15 ligands; including α-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit; which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP); a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP; which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1; which is expressed in brain; liver and lung; is also implicated in Alzheimer s disease (AD); as the human LRP gene localizes to a potential AD locus on chromosome 12.
Host:
Mouse
Immunogen:
Recombinant fragment of human LRP1 protein (exact sequence is proprietary)
Isotype:
IgG1
Molecular Weight:
85/515/600kDa
Research Area:
Cardiovascular; Neuroscience
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody