Galectin-9 (LGALS9) (Marker of T-Cell Exhaustion) Antibody
Product Sizes
20 ug
£364.00
3965-MSM5-P0-20UG
About this Product
- SKU:
- 3965-MSM5-P0
- Additional Names:
- Ecalectin | Tumor antigen HOM-HD-21
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- LGALS9/7689
- Clonality:
- Monoclonal
- Extra Details:
- Galectins are a family of soluble β-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) interactions and play a role in tumor progression; pre-mRNA splicing and apoptosis. One member of this family; Galectin-9; also known as Ecalectin; Gal-9; hUAT2; HOM-HD-21 or LGALS9; maps to human chromosome 17 and encodes a 36 kDa protein. Galectin-9 is an integral membrane protein that exists as two isoforms; a long form and a short form; which differ by an internal stretch of 32 amino acids. Galectin-9 is an eosinophile chemoattractant produced by activated T lymphocytes that is expressed in organs of the gastrointestinal tract; aorta; liver; kidney; liver; pancreatic islets; lung; tonsil and some colorectal carcinoma; and in the cell lines HUVEC; U-937; HL60; HeLa and Jurkat. Introduction of IL-1beta enhances Galectin-9 expression. Increased expression of Galectin-9 induces apoptosis in thymocytes and CD8+ cells. Galectin-9 is involved in immuno/inflammation processes in potential-sensitive uric acid translocation and contributes to inflammatory reactions in the central nervous system (CNS).
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa200-355) of human LGALS9 protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 36kDa
- Research Area:
- Apoptosis; Cancer; Immuno Oncology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=145138
