HES5 / bHLHb38 / Hes family bHLH transcription factor 5 Antibody
Product Sizes
100 ug
£671.00
388585-MSM1-P1-100UG
About this Product
- SKU:
- 388585-MSM1-P1
- Additional Names:
- bHLHb38 antibody; Class B basic helix-loop-helix protein 38 antibody; Hairy and enhancer of split 5 antibody; Hairy/Enhancer of spli; Drosophila; homolog of; 5 antibody; HES 5 antibody; hes family bHLH transcription factor 5 antibody; Hes5 antibody; HES5 protein antibody; HES5_HUMAN antibody; MGI:104876 antibody; Transcription factor HES-5 antibody
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- HES5/8035
- Clonality:
- Monoclonal
- Extra Details:
- The Drosophila Hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila Hairy and Enhancer of split are the HES gene family members; HES1-6; which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE; the mammalian homologue of Groucho; and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA; instead of interfering with activator proteins. Most HES family members; including HES1 and HES5; preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites; while HES6 does not bind DNA. Rather; HES6 inhibits HES1 activity; thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells; and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human HES5 protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 41kDa
- Research Area:
- Neuroscience
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 4 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=139352
