Recombinant Cytokeratin 17 (CK17) (Basal Epithelial Marker) Antibody
Product Sizes
20 ug
£431.00
3872-RBM11-P0-20UG
About this Product
- SKU:
- 3872-RBM11-P0
- Additional Names:
- 39.1 | Cytokeratin-17 | Keratin-17
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MSVA-117R
- Clonality:
- Monoclonal
- Extra Details:
- CK17 is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands ÔøΩsuch as mammary; sweat and salivary. CK17 is expressed in epithelial cells of various origins; such as bronchial epithelial cells and skin appendages. It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. Additionally; anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment of human KRT17 protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 46kDa
- Research Area:
- Basal Cell Marker; Developmental Biology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=147486
