Interleukin-31 / IL-33 Antibody
Product Sizes
100 ug
£671.00
386653-MSM3-P1-100UG
About this Product
- SKU:
- 386653-MSM3-P1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- IL31/7333
- Clonality:
- Monoclonal
- Extra Details:
- IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1; JAK2; Stat1; Stat3 and Stat5 signaling pathways; as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells; more numerous in skin from patients with AD compared with that of healthy individuals; expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis; and may represent a novel target for antipruritic drug development.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-164) of human IL31 protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 18 kDa
- Research Area:
- Cytokine Signaling; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=131569
