Recombinant Cytokeratin 10 (KRT10) (Suprabasal Epithelial Marker) Antibody

Product Sizes

20 ug

£364.00

3858-RBM14-P0-20UG

About this Product

SKU:: 3858-RBM14-P0
Additional Names:: Cytokeratin-10 | Keratin-10
Application:: Immunohistochemistry, Western Blot
translate.label.attr.clone:: KRT10/7804R
Clonality:: Monoclonal
Extra Details:: This MAb recognizes a protein of 56.5kDa; identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis; expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer; appears in the first suprabasal layers and increases in concentration towards the granular layer. However; CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm; clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm; clinical stages II and III); CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes; being preferentially detected in more-differentiated parts.
Host:: Rabbit
Immunogen:: Recombinant human fragment (around aa 500-600) of human KRT10 protein (exact sequence is proprietary)
Isotype:: IgG
Molecular Weight:: 56.5kDa
Research Area:: Developmental Biology
Shipping Conditions:: Blue Ice
Storage Conditions:: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:: NeoBiotechnologies
Type:: Antibodies: Monoclonal Antibody

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