Cytokeratin 6 (Basal Cell Marker) Antibody
Product Sizes
20 ug
£364.00
3853-MSM1X-P0-20UG
About this Product
- SKU:
- 3853-MSM1X-P0
- Additional Names:
- Cytokeratin-6A | Cytokeratin-6D | Keratin-6A | Type-II keratin Kb6
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry
- translate.label.attr.clone:
- SPM269
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes a protein of 56kDa; identified as cytokeratin 6 (CK6). In humans; multiple isoforms of Cytokeratin 6 (6A-6F); encoded by several highly homologous genes; have distinct tissue expression patterns; and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13; and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes; which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles; suprabasal cells of a variety of internal stratified epithelia; in epidermis; in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes; which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.
- Host:
- Mouse
- Immunogen:
- A synthetic peptide of 11 amino acids (GSSTIKYTTTS) from C-terminus of human keratin 6
- Isotype:
- IgG2a
- Molecular Weight:
- 56kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=116888
