Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody
Product Sizes
100 ug
£671.00
3713-MSM1-P1-100UG
About this Product
- SKU:
- 3713-MSM1-P1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- SY5
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a protein of 66kDa-170kDa; identified as involucrin. In Western blotting of cultured human keratinocytes; this MAb reacts with a 120kDa protein. It stains the involucrin in a variety of sizes: 170kDa in MCF-7 cells; a doublet of ~115kDa and 150kDa in gorilla and owl monkey; 66kDa in dog; and a doublet of 105kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia; including the cornea; which lacks a distinct cornified layer. In normal epidermis; it is first expressed in the upper spinous layers; and in keratinocyte cultures; all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias; involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions; and is reduced in severe dysplasias of the larynx and cervix.
- Host:
- Mouse
- Immunogen:
- Purified involucrin from human keratinocytes
- Isotype:
- IgG1
- Molecular Weight:
- 66-170kDa
- Research Area:
- Autophagy; Developmental Biology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=116708
