CD11b / MAC-1 (Microglial Marker) Antibody
Product Sizes
100 ug
£671.00
3684-MSM11-P1-100UG
About this Product
- SKU:
- 3684-MSM11-P1
- Additional Names:
- CD11 antigen-like family member B | CR-3 alpha chain | Cell surface glycoprotein MAC-1 subunit alpha | Leukocyte adhesion receptor MO1 | Neutrophil adherence receptor
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- ITGAM/4741
- Clonality:
- Monoclonal
- Extra Details:
- CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin à �M combines with the Integrin � �2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1); or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin à �M/ � �2 is important in the adherence of neutrophils and monocytes to stimulated endothelium; and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes; macrophages; natural killer (NK) cells; and granulocytes. It is part of a heterodimer that consists of CD11b and �CD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa900-1100) of human ITGAM protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 95kDa & 170kDa
- Research Area:
- AKT Signaling; Cardiovascular; Complement System; Cytokine Signaling; Dendritic Cell Marker; Hematopoietic Stem Cells; Immunology; Mesenchymal Stem Cell Differentiation; Neuroscience
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=134759
