IRS1 (Insulin receptor substrate 1) Antibody
Product Sizes
20 ug
£364.00
3667-MSM1-P0-20UG
About this Product
- SKU:
- 3667-MSM1-P0
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- IRS1/7571
- Clonality:
- Monoclonal
- Extra Details:
- The Insulin receptor substrate-1 (IRS-1); a protein major substrate of the Insulin receptor; is phosphorylated in response to stimulation of cells by Insulin; Insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine; threonine and tyrosine residues in a variety of tissues. An Insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the Insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase IIcatalyzed phosphorylation site in rat IRS-1; and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus; casein kinase IIcatalyzed phosphorylation of IRS-1 may be a component of the intracellular Insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270; Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphotyrosine binding domain of IRS-1; which is responsible for the interaction with the Insulin receptor. The association of 14-3-3 with IRS-1 increases significantly upon treatment with okadaic acid; a potent serine/threonine phosphatase inhibitor. Therefore; the association of 14-3-3 protein may play a role in the regulation of Insulin sensitivity by interrupting the association between the Insulin receptor and IRS-1.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human IRS1 protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 170-185kDa
- Research Area:
- AKT Signaling; Cardiovascular; Cytokine Signaling; Immunology; Infectious Disease; Neuroinflammation; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=133860
