IRF3 Antibody
Product Sizes
100 ug
£671.00
3661-MSM2-P1ABX-100UG
About this Product
- SKU:
- 3661-MSM2-P1ABX
- Application:
- Immunofluorescence, Western Blot
- translate.label.attr.clone:
- PCRP-IRF3-1E11
- Clonality:
- Monoclonal
- Extra Details:
- Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-伪and 尾) and interferon-inducible genes. The two factors are structurally related; particularly in their N-terminal regions; which confer DNA binding specificity. In addition; both bind to the same sequence within the promoters of interferon-伪and interferon-尾genes. IRF-1 functions as an activator of interferon transcription; while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3; IRF-4; IRF-5; IRF-6; IRF-7; ISGF-3纬p48 and IFN consensus sequence-binding protein (ICSBP).
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human IRF3 protein
- Isotype:
- IgG1
- Molecular Weight:
- ~50kDa
- Research Area:
- Cardiovascular; Cytokine Signaling; Immunology; Infectious Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=116557
