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Antibodies

Pancreatic duodenal homeobox-1 protein (PDX1) Antibody

Product Sizes
100 ug
£671.00
3651-MSM1-P1ABX-100UG
About this Product
SKU:
3651-MSM1-P1ABX
Additional Names:
Glucose-sensitive factor | Insulin promoter factor 1 | Insulin upstream factor 1 | Islet/duodenum homeobox-1 | Somatostatin-transactivating factor 1
Application:
Flow Cytometry, Immunofluorescence
translate.label.attr.clone:
PCRP-PDX1-2C11
Clonality:
Monoclonal
Extra Details:
Pancreatic duodenal homeobox-1 protein (PDX-1); also designated Insulin promoter factor (IPF1); Insulin upstream factor 1 (IUF1); somatostatin transactivating factor-1 (STF-1) and glucose-sensitive factor (GSF); is a 282 amino acid homeodomain-containing transcription factor present in pancreatic 尾-cells. PDX-1 is a key regulator of pancreatic islet development and Insulin gene transcription in 尾-cells. PDX-1 is expressed in all cells at the early stages of development and is mainly restricted to the pancreas and duodenum in adult. HNF-3尾; HNF-1伪 and SP1 positively regulate the PDX-1 enhancer element. PDX-1 is also regulated by Glucagon-like peptide through activation of adenylyl cyclase; which results in an increase in intracellular cAMP activity. The increased levels of cAMP; and the resulting activation of PKA; lead to an increase in PDX-1 transcription and translocation of the protein to the nuclei of 尾-cells. PDX-1 binds to the sequence C(C/T) and can heterodimerize with PBX. PDX-1 is phosphorylated by the SAPK2 pathway under high glucose concentrations. Mutations in the PDX-1 gene can cause maturity-onset diabetes of the young and pancreatic agenesis. The gene which encodes PDX-1 maps to human chromosome 13q12.2.
Host:
Mouse
Immunogen:
Recombinant full-length human PDX1 protein
Isotype:
IgG2c
Molecular Weight:
46kDa
Research Area:
Cardiovascular; Developmental Biology; Nuclear Marker; Stem Cell Differentiation
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody