Pancreatic duodenal homeobox-1 protein (PDX1) Antibody
Product Sizes
20 ug
£364.00
3651-MSM1-P0-20UG
About this Product
- SKU:
- 3651-MSM1-P0
- Additional Names:
- Glucose-sensitive factor | Insulin promoter factor 1 | Insulin upstream factor 1 | Islet/duodenum homeobox-1 | Somatostatin-transactivating factor 1
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-PDX1-2C11
- Clonality:
- Monoclonal
- Extra Details:
- Pancreatic duodenal homeobox-1 protein (PDX-1); also designated Insulin promoter factor (IPF1); Insulin upstream factor 1 (IUF1); somatostatin transactivating factor-1 (STF-1) and glucose-sensitive factor (GSF); is a 282 amino acid homeodomain-containing transcription factor present in pancreatic 尾-cells. PDX-1 is a key regulator of pancreatic islet development and Insulin gene transcription in 尾-cells. PDX-1 is expressed in all cells at the early stages of development and is mainly restricted to the pancreas and duodenum in adult. HNF-3尾; HNF-1伪 and SP1 positively regulate the PDX-1 enhancer element. PDX-1 is also regulated by Glucagon-like peptide through activation of adenylyl cyclase; which results in an increase in intracellular cAMP activity. The increased levels of cAMP; and the resulting activation of PKA; lead to an increase in PDX-1 transcription and translocation of the protein to the nuclei of 尾-cells. PDX-1 binds to the sequence C(C/T) and can heterodimerize with PBX. PDX-1 is phosphorylated by the SAPK2 pathway under high glucose concentrations. Mutations in the PDX-1 gene can cause maturity-onset diabetes of the young and pancreatic agenesis. The gene which encodes PDX-1 maps to human chromosome 13q12.2.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human PDX1 protein
- Isotype:
- IgG2c
- Molecular Weight:
- 46kDa
- Research Area:
- Cardiovascular; Developmental Biology; Nuclear Marker; Stem Cell Differentiation
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=116551
