Recombinant INSM1 (Pan-Neuroendocrine Marker) Antibody
Product Sizes
100 ug
£671.00
3642-RBM11-P1ABX-100UG
About this Product
- SKU:
- 3642-RBM11-P1ABX
- Additional Names:
- Zinc finger protein IA-1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- INSM1/8149R
- Clonality:
- Monoclonal
- Extra Details:
- Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95% of lung small cell carcinoma and 91% of lung large cell neuroendocrine carcinoma; compared with 75% and 78% with the combined panel of traditional neuroendocrine markers (synaptophysin; chromogranin; and CD56).INSM1 stains 100% of the atypical carcinoids; typical carcinoids and paragangliomas; but only 3% of adenocarcinomas and 4% of squamous cell carcinomas. Therefore; INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa1-300) corresponding to the N-terminus of human INSM1
- Isotype:
- IgG
- Molecular Weight:
- 58kDa
- Research Area:
- Developmental Biology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=128586
