IL-6 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody
Product Sizes
100 ug
£671.00
3606-MSM4-P1-100UG
About this Product
- SKU:
- 3606-MSM4-P1
- Additional Names:
- Iboctadekin | Interferon gamma-inducing factor | Interleukin-1 gamma
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- IL18/4624
- Clonality:
- Monoclonal
- Extra Details:
- Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1α; IL-1β and IL-1γ/IL-18 and a specific receptor antagonist; IL-1Rα. IL-1α and IL-1β play critical roles in the regulation of the immune response and inflammation; serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1γ) has been shown to augment the secretion of IFN-γ from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1α and IL-1β respectively over the 12 β-strands of the β-trefoil fold domain; which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1β pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-γ-inducing factor); IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-193) of human IL-18 protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 18kDa
- Research Area:
- AKT Signaling; Cardiovascular; Cytokine Signaling; Immunology; Infectious Disease; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=134735
