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Antibodies

IL-6 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody

Product Sizes
20 ug
£364.00
3606-MSM2-P0-20UG
About this Product
SKU:
3606-MSM2-P0
Additional Names:
Iboctadekin | Interferon gamma-inducing factor | Interleukin-1 gamma
Application:
Immunohistochemistry, Western Blot
translate.label.attr.clone:
IL18/4622
Clonality:
Monoclonal
Extra Details:
Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1α; IL-1β and IL-1γ/IL-18 and a specific receptor antagonist; IL-1Rα. IL-1α and IL-1β play critical roles in the regulation of the immune response and inflammation; serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1γ) has been shown to augment the secretion of IFN-γ from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1α and IL-1β respectively over the 12 β-strands of the β-trefoil fold domain; which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1β pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-γ-inducing factor); IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).
Host:
Mouse
Immunogen:
Recombinant fragment (around aa1-193) of human IL-18 protein (exact sequence is proprietary)
Isotype:
IgG2
Molecular Weight:
18kDa
Research Area:
AKT Signaling; Cardiovascular; Cytokine Signaling; Immunology; Infectious Disease; Nuclear Marker
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody