Interleukin-3 (IL-3) Antibody
Product Sizes
100 ug
£671.00
3562-MSM5-P1-100UG
About this Product
- SKU:
- 3562-MSM5-P1
- Additional Names:
- Hematopoietic growth factor | Mast cell growth factor | Multipotential colony-stimulating factor | P-cell-stimulating factor
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- IL3/4005
- Clonality:
- Monoclonal
- Extra Details:
- Interleukin-3; or IL-3; is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors; but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific 伪 subunit and a signal transducing 尾 subunit common to the IL-3/IL-5/GM-CSF receptors. The carboxy terminus of the 尾 subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity; stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member; JAK2; which in turn activates and causes nuclear translocation of Stat5a and Stat5b.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human IL3 protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 17kDa
- Research Area:
- AKT Signaling; Cardiovascular; Cytokine Signaling; Hematopoietic Stem Cells; Immunology; Signal Transduction; Stem Cell Differentiation; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=116374
