Fas Ligand (FASLG) Antibody
Product Sizes
100 ug
£671.00
356-MSM3-P1-100UG
About this Product
- SKU:
- 356-MSM3-P1
- Additional Names:
- Apoptosis antigen ligand | CD95 ligand | Fas antigen ligand
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- FASLG/4453
- Clonality:
- Monoclonal
- Extra Details:
- Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an importantcomponent of specific effector mechanisms in immuno-surveillance againstvirus-infected or transformed cells. Two mechanisms appear to account forthis activity; one of which is the perforin-based process. Independently; aFAS-based mechanism involves the transducing molecule FAS (also designated Apo-1) and its ligand (FAS-L). The human FAS protein is a cell surfaceglycoprotein that belongs to a family of receptors that includes CD40; nervegrowth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines; certain of whichundergo apoptosis in response to treatment with antibody to FAS. Thesefindings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors; and that FASmay be critically involved in CTL-mediated cytotoxicity.
- Host:
- Mouse
- Immunogen:
- Human recombinant FASLG protein fragment (around aa107-222) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 26kDa (soluble FAS-L) / 40kDa (FAS-L membrane)
- Research Area:
- AKT Signaling; Apoptosis; Autophagy; Cardiovascular; Complement System; Cytokine Signaling; Defective Intrinsic Apoptosis; Immunology; Infectious Disease; MAPK Signaling; Signal Transduction; Transcri
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=116346
