Recombinant CD25 / IL2RA (Activated Lymphocyte Marker) Antibody
Product Sizes
100 ug
£671.00
3559-MSM14-P1ABX-100UG
About this Product
- SKU:
- 3559-MSM14-P1ABX
- Additional Names:
- TAC antigen | p55
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- rIL2RA/12624
- Clonality:
- Monoclonal
- Extra Details:
- CD25 is the alpha chain of the IL-2 receptor. It is a Type I transmembrane protein present on activated T-cells; activated B-cells; some thymocytes; myeloid precursors; and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2. It is expressed in most B-cell neoplasms; some Acute Non-lymphocytic Leukemias; and Neuroblastomas. Expression of CD25 is a reliable diagnostic tool for distinguishing neoplastic mast-cell aggregates from reactive proliferations; and has; therefore; recently become a minor criterion for the diagnosis of Systemic Mastocytosis (SM). Anti-CD25 antibodies have also been useful in identifying mast cells in skin biopsies in the setting of Urticaria Pigmentosa; which is predictive of Systemic Mastocytosis. Quantitation of regulatory T-cells (Treg) in the setting of hepatocellular carcinoma has been used as an independent predictive factor for tumor recurrence after hepatic resection for HCC. Also; the percentage of tumor-infiltrating CD25+FOXP3+regulatory T-cells among tumor cells; inside tumor parenchyma and at its periphery are significantly higher in recurrent Cutaneous Melanoma than in Non-recurrent Melanoma.
- Host:
- Mouse
- Immunogen:
- Recombinant human fragment corresponding to the external domain of the IL2RA protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 31kDa
- Research Area:
- AKT Signaling; B Cell Markers; Cardiovascular; Cytokine Signaling; Hematopoietic Stem Cells; Immune checkpoint; Immunology; Mast Cell Marker; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=144445
