IL1RN / IL-1RN / IL1RA (Interleukin-1RA) Antibody
Product Sizes
100 ug
£671.00
3557-MSM2-P1ABX-100UG
About this Product
- SKU:
- 3557-MSM2-P1ABX
- Additional Names:
- ICIL-1RA | IL1 inhibitor
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- IL1RA/4712
- Clonality:
- Monoclonal
- Extra Details:
- Two forms of interleukin-1; designated IL-1a and IL-1β; have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity; IL-1a and IL-1β bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation; but it has also been shown to be expressed during kidney development; thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation acting as an activator of T and B lymphocytes and natural killer (NK) cells. IL-1 receptor antagonist (IL-1ra) is a cytokine that inhibits IL-1a and IL-1β binding to interleukin receptors. By neutralizing the activity of IL-1; IL-1ra contributes to the inhibition of the immune and inflammatory responses and has been targeted as a drug for the treatment of severely active rheumatoid arthritis. There are four isoforms of IL-1ra that are produced as a result of alternative splicing events.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human Interleukin-1RA protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 17-25kDa
- Research Area:
- Cardiovascular; Cytokine Signaling; Immunology; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=133714
