Interleukin-1 beta (IL-1 beta) Antibody
Product Sizes
100 ug
£671.00
3553-MSM11-P1-100UG
About this Product
- SKU:
- 3553-MSM11-P1
- Additional Names:
- Catabolin
- Application:
- ELISA, Immunohistochemistry
- translate.label.attr.clone:
- IL1B/4651
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 17-31kDa; identified as interleukin 1beta. It shows no cross-reaction with interleukin 1alpha. Epitopes of MAb IL1B/463 and IL1B/4651 are different and provide a good pair for developing an ELISA. This cytokine is produced by activated macrophages as a proprotein; which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response; and is involved in a variety of cellular activities; including cell proliferation; differentiation; and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa100-269) of human IL1B protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 31kDa (proprotein); 17kDa (mature)
- Research Area:
- AKT Signaling; Cardiovascular; Cytokine Signaling; Immunology; Infectious Disease; MAPK Signaling; Neuroinflammation
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=129281
