CD95 / FAS / TNFRSF6 Antibody
Product Sizes
100 ug
£671.00
355-MSM2-P1ABX-100UG
About this Product
- SKU:
- 355-MSM2-P1ABX
- Additional Names:
- Apo-1 antigen | Apoptosis-mediating surface antigen FAS | FASLG receptor
- Application:
- ELISA, Immunohistochemistry
- translate.label.attr.clone:
- FAS/3112
- Clonality:
- Monoclonal
- Extra Details:
- This MAb specifically recognizes CD95; also known as Fas; a transmembrane glycoprotein with a MW of 40-45kDa; containing 8kDa of N-glycoside-linked polysaccharide. It is a receptor for TNFSF6/FASLG; a member of the nerve growth factor receptor/tumor necrosis factor superfamily; mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation; which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance; in the antigen-stimulated suicide of mature T-cells; or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types; preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa26-96) of human CD95 (FAS) protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 38-50kDa
- Research Area:
- AKT Signaling; Apoptosis; Autophagy; Cardiovascular; Complement System; Endothelial Cell Marker; MAPK Signaling; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=116284
