Recombinant IgG4 (Fc) (Ig Heavy Constant Gamma 4) Antibody
Product Sizes
20 ug
£364.00
3503-RBM5-P0-20UG
About this Product
- SKU:
- 3503-RBM5-P0
- Additional Names:
- Ig gamma-4 chain C region
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- IGHG4/13367R
- Clonality:
- Monoclonal
- Extra Details:
- IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level; sclerosing fibrosis; and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. Clinical manifestations are apparent in the pancreas; bile duct; gall bladder; lacrimal gland; salivary gland; retroperitoneum; kidney; lung; breast; thyroid; and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibit significantly more than normal IgG4-positive plasma cells in affected tissues but also significantly higher IgG4/IgG ratios (typically > 30%). IgG4 antibodies will dominate the IgG response in schistosomiasis; lymphatic filariasis; and in patients after allergen immunotherapy. Unlike the other IgG subclasses; IgG4 does not activate complement. A combined IgA-IgG4 deficiency has been associated with recurrent pyogenic infections.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa1-200) of human IGHG4 protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 36kDa
- Research Area:
- B Cell Markers
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=148274
