IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Antibody
Product Sizes
100 ug
£671.00
3503-MSM1-P1-100UG
About this Product
- SKU:
- 3503-MSM1-P1
- Additional Names:
- Ig gamma-4 chain C region
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- IGHG4/1345
- Clonality:
- Monoclonal
- Extra Details:
- The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions; the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly; a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level; sclerosing fibrosis; and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells.IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH); there are an increased number of IgG4+ plasma cells.
- Host:
- Mouse
- Immunogen:
- Recombinant human IGHG4 fragment
- Isotype:
- IgG1
- Molecular Weight:
- 150kDa
- Research Area:
- B Cell Markers
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=116015
