IGF1R alpha / CD221 Antibody
Product Sizes
100 ug
£671.00
3480-MSM6-P1ABX-100UG
About this Product
- SKU:
- 3480-MSM6-P1ABX
- Additional Names:
- Insulin-like growth factor I receptor
- Application:
- Immunocytochemistry, Immunofluorescence
- translate.label.attr.clone:
- 24-60
- Clonality:
- Monoclonal
- Extra Details:
- This antibody is specific for the human insulin-like growth factor 1 receptor (IGF1R). It recognizes the extracellular portion of the receptor; specifically an epitope in the cysteine rich domain of the alpha subunit; between amino acids 184 and 283. It does not cross-react with rat or mouse IGF1R or human insulin receptors in co-precipitation or immunodepletion assays. The ability of this antibody to bind human IGF1R has been confirmed in IGF1 binding assays using both IG1FR-overexpressing IGF1R/3T3 cells and soluble receptors (Soos et al; 1992). This antibody efficiently precipitates human IGF1R solubilised from IGF1R/3T3 cells (Soos et al; 1992) and human placental membranes (Bailyes et al; 1997); and has been used in immunoprecipitation analysis of 293 cells transfected with IGF1R or chimeric IGF1R-insulin receptor (IR) constructs (Schumacher et al; 1993). When immobilised; this antibody has been shown to remove essentially all soluble; IGF1R/3T3-derived IGF1R (Soos et al; 1992) and human placental membrane-derived IGF1R (Soos et al; 1993) in immunodepletion experiments. This antibody strongly inhibits IGF1 binding to its receptor (Soos et al; 1992); and has been shown to suppress IGF1-mediated stimulation of skin fibroblast proliferation (Okubo et al 2003).
- Host:
- Mouse
- Immunogen:
- IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA
- Isotype:
- IgG2a
- Molecular Weight:
- 130kDa (IGF-1R); 97kDa (IGF-1R); 200kDa (pro-IGF-1R)
- Research Area:
- AKT Signaling; Breast Cancer; Cardiovascular; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=139918
