IGF1R / CD221 Antibody
Product Sizes
100 ug
£671.00
3480-MSM1-P1-100UG
About this Product
- SKU:
- 3480-MSM1-P1
- Additional Names:
- Insulin-like growth factor I receptor
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- IGF1R/4667
- Clonality:
- Monoclonal
- Extra Details:
- Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle; cell migration; cell metabolism; cell survival; proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types; blocks apoptosis; acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc; GRB2 and Sos 1; which initiates Ras and ERK kinase cascades; thereby modifying transcription factor activity; such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of Insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1;376 amino acid precursor protein that cleaves into 伪 and 尾 subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2;491 amino acid transmembrane protein.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa550-750) of human IGF1R protein (exact sequence is proprietary)
- Isotype:
- IgG2c
- Molecular Weight:
- 130kDa (IGF-1R); 97kDa (IGF-1R); 200kDa (pro-IGF-1R)
- Research Area:
- AKT Signaling; Breast Cancer; Cardiovascular; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115928
