Recombinant IDH1-R132G (Isocitrate Dehydrogenase) Antibody
Product Sizes
20 ug
£364.00
3417-RBM13-P0-20UG
About this Product
- SKU:
- 3417-RBM13-P0
- Additional Names:
- Cytosolic NADP-isocitrate dehydrogenase | IDPc | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- IDH1.R132G/13054R
- Clonality:
- Monoclonal
- Extra Details:
- The gene represented in this entry is involved in disease pathogenesis. Mutations affecting Arg-132 are tissue-specific; and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys; His; Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead; alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors. Genetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma. Mutations of Arg-132 to Cys; Gly or His abolish the conversion of isocitrate to alpha-ketoglutarate. Instead; alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment of human IDH1 protein with R132G (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 45-47kDa
- Research Area:
- Cardiovascular; Immunology; Infectious Disease; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=141558
