IDH1 (Isocitrate Dehydrogenase) Antibody
Product Sizes
100 ug
£671.00
3417-MSM2-P1-100UG
About this Product
- SKU:
- 3417-MSM2-P1
- Additional Names:
- Cytosolic NADP-isocitrate dehydrogenase | IDPc | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase
- Application:
- Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- IDH1/1152
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a 45kDa protein; which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle; which involves the oxidative decarboxylation of isocitrate; forming 伪-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate; while the second step involves the production of 伪-ketoglutarate. During this process; either NADH or NADPH is produced along with CO2. Recently; an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that; when mutationally inactivated; contributes to tumorigenesis in part through induction of the HIF-1 pathway.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human IDH1 protein (around aa 281-414) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 45-47kDa
- Research Area:
- Cardiovascular; Immunology; Infectious Disease; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115833
