ID1 (Inhibitor of DNA-binding) (Transcription Factor) Antibody
Product Sizes
20 ug
£364.00
3397-MSM3-P0-20UG
About this Product
- SKU:
- 3397-MSM3-P0
- Additional Names:
- Class B basic helix-loop-helix protein 24 | Inhibitor of DNA binding 1 | Inhibitor of differentiation 1
- Application:
- ELISA, Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-ID1-2F11
- Clonality:
- Monoclonal
- Extra Details:
- Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1; Id2; Id3 and Id4. They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins. Due to the absence of the basic region; the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D; it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation; the Id protein levels fall; allowing E12 and/or E47 to form heterodimers with Myo D and myogenin; which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (aa 5-150) of human ID1
- Isotype:
- IgG1
- Molecular Weight:
- 16.13kDa
- Research Area:
- Endothelial Cell Marker; Nuclear Marker; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115807
