Heparan Sulfate Proteoglycan (Large) / Perlecan Antibody
Product Sizes
20 ug
£364.00
3339-RTM1X-P0-20UG
About this Product
- SKU:
- 3339-RTM1X-P0
- Additional Names:
- Perlecan
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry
- translate.label.attr.clone:
- SPM255
- Clonality:
- Monoclonal
- Extra Details:
- This MAb specifically precipitates heterogeneous material of high MW; identified as perlecan; a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin; fibronectin; or dermatran sulfate proteoglycan. Because of perlecan's strategic location and ability to store and protect growth factors; it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus; perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
- Host:
- Rat
- Immunogen:
- Murine EHS laminin preparation
- Isotype:
- IgG2a
- Molecular Weight:
- >400kDa
- Research Area:
- Cardiovascular; Endothelial Cell Marker; Infectious Disease; Mesenchymal Stem Cell Differentiation; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115716
