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Antibodies

HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) Antibody

Product Sizes
100 ug
£671.00
3329-MSM8-P1ABX-100UG
About this Product
SKU:
3329-MSM8-P1ABX
Additional Names:
60 kDa chaperonin | Chaperonin 60 | Heat shock protein 60 | HuCHA60 | Mitochondrial matrix protein P1 | P60 lymphocyte protein
Application:
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
translate.label.attr.clone:
CPTC-HSPD1-1
Clonality:
Monoclonal
Extra Details:
The heat shock proteins (HSPs) comprise a group of highly conserved; abundantly expressed proteins with diverse functions; including the assembly and sequestering of multiprotein complexes; transportation of nascent polypeptide chains across cellular membranes; and the regulation of protein folding. The mitochondrial and cytosolic localization of HSP60; combined with its binding and catalysis of folding of newly synthesized proteins destined for the mitochondrial matrix; classify this protein as a molecular chaperone. An additional role of HSP 60 is to act as a cell surface marker for 纬/ �L T cell recognition; as well as being involved in a danger signal cascade immune response. HSP60 has been shown to influence apoptosis in tumor cells; and changes in its expression level may serve as a biomarker; as down-regulated HSP60 expression indicates a poor prognosis as well as a risk of tumor infiltration development; especially with regard to urothelial carcinomas. In ovarian cancer; decreased expression of HSP60 correlates with aggressive tumor types; while overexpression is correlated with a better patient prognosis.
Host:
Mouse
Immunogen:
Recombinant full-lengthhuman HSPD1 protein
Isotype:
IgG1
Molecular Weight:
60kDa
Research Area:
Cardiovascular; Mitochondria Marker; Ovarian Cancer; Transcription Factors
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody