Survivin / BIRC5 Antibody
Product Sizes
100 ug
£671.00
332-MSM13-P1ABX-100UG
About this Product
- SKU:
- 332-MSM13-P1ABX
- Additional Names:
- Apoptosis inhibitor 4 | Apoptosis inhibitor survivin
- Application:
- Western Blot
- translate.label.attr.clone:
- BIRC5/9073
- Clonality:
- Monoclonal
- Extra Details:
- The baculovirus protein p35 inhibits virally induced apoptosis of invertebrate and mammalian cells and may function to impair the clearing of virally infected cells by the host s immune system. This is accomplished at least in part by its ability to block both TNF- and FAS-mediated apoptosis through the inhibition of the ICE family of serine proteases. Two mammalian homologs of baculovirus p35; referred to as inhibitor of apoptosis protein (IAP) 1 and 2; share an amino terminal baculovirus IAP repeat (BIR) motif and a carboxy terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R); they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors; TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3; leading to the resistance of FAS-mediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivin-microtubule interactions occurs.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-142) of human BIRC5 protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 17kDa
- Research Area:
- Apoptosis; Autophagy; Colon Cancer; Cytokine Signaling; Immunology; Ovarian Cancer; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=137906
