APEX Nuclease I Antibody
Product Sizes
100 ug
£671.00
328-MSM1-P1-100UG
About this Product
- SKU:
- 328-MSM1-P1
- Additional Names:
- APEX nuclease | Apurinic-apyrimidinic endonuclease 1 | REF-1 | Redox factor-1
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- CPTC-APEX1-2
- Clonality:
- Monoclonal
- Extra Details:
- APEX / APE1 is a multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Patients with genetic variants in APEX1 and XRCC1 have been shown to have a higher risk of lung cancer. Elevated APEX1 levels observed in human testicular cancer may be related to relative resistance to therapy and therefore may serve as a diagnostic marker for refractory disease.
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length APEX1 protein
- Isotype:
- IgG1
- Molecular Weight:
- 35kDa
- Research Area:
- Neuroscience; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115620
