Haptoglobin (HP) Antibody
Product Sizes
100 ug
£671.00
3240-MSM4-P1ABX-100UG
About this Product
- SKU:
- 3240-MSM4-P1ABX
- Additional Names:
- Zonulin
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- HP/3834
- Clonality:
- Monoclonal
- Extra Details:
- Haptoglobin (Hp) is a blood plasma protein that functions to bind free Hemoglobin that has been released from erythrocytes; thereby inhibiting its oxidative activity. During this process; Haptoglobin sequesters the iron within Hemoglobin; preventing iron-utilizing bacteria from benefitting from hemolysis. This function suggests that Haptoglobin concentrations may increase in response to inflammation. The resulting Haptoglobin-Hemoglobin complex is then removed by the reticulo-endothelial system. Due to cleavage of a common precursor protein during protein synthesis; Haptoglobin consists of two a and two b chains; connected by disulfide bridges. In human; Haptoglobin exists in two allelic forms designated Haptoglobin 1 (Hp1) and Haptoglobin 2 (Hp2); where Hp2 is the result of a partial Hp1 gene duplication. There are three known phenotypes of human Haptoglobin: Hp1-1; Hp2-1 and Hp2-2; which may be associated with diabetes and cardiovascular disease pathology and a susceptibility to Parkinson s and Crohn s disease. Haptoglobin levels are useful in diagnosing hemolytic anemia; the abnormal breakdown of red blood cells. Haptoglobin is expressed in mammalian hepatocytes as well as other tissues such as skin; lung and kidney.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa100-250) of human HP protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 15-18 kDa ( chain); 45kDa ( chain)
- Research Area:
- Cardiovascular; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=133596
