Recombinant APC / Adenomatous Polyposis Coli / FAP (Tumor Suppressor) Antibody
Product Sizes
20 ug
£364.00
324-MSM4-P0-20UG
About this Product
- SKU:
- 324-MSM4-P0
- Additional Names:
- Deleted in polyposis 2.5
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- rEMM43
- Clonality:
- Monoclonal
- Extra Details:
- The human adenomatous polyposis coli (APC) gene at locus 5q21 encodes a protein of 2;843 amino acids. The precise function of this 300 kD protein is not clear but it may have several functions including a role in cell proliferation; apoptosis; expression of cell adhesion proteins and modulation of cell to cell interactions. It is reported to be expressed in the cytoplasm of cell types of many lineages; both epithelial and mesenchymal. In the epithelium of bladder; small and large intestine; esophagus; stomach and epidermis; APC expression is restricted to regions in which cell replication has ceased and terminal differentiation has been established. Expression has been observed in lung; liver; kidney and mammary gland endothelial; myoepithelial and duct lining epithelial cells. Some tissues such as ovary; myometrium; thyroid; parathyroid and tonsil do not express the protein.
- Host:
- Mouse
- Immunogen:
- Prokaryotic recombinant protein corresponding to a 251 amino acid region of the C-terminus of the human adenomatous polyposis coli protein
- Isotype:
- IgG2b
- Molecular Weight:
- 66kDa
- Research Area:
- Apoptosis; Breast Cancer; Cardiovascular; Colon Cancer; Infectious Disease; Ovarian Cancer; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=141403
