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Antibodies

APC / Adenomatous Polyposis Coli / FAP (Tumor Suppressor) Antibody

Product Sizes
100 ug
£671.00
324-MSM1-P1ABX-100UG
About this Product
SKU:
324-MSM1-P1ABX
Additional Names:
Deleted in polyposis 2.5
Application:
ELISA, Flow Cytometry, Immunofluorescence, Western Blot
translate.label.attr.clone:
ALi 12-28
Clonality:
Monoclonal
Extra Details:
The adenomatous polyposis syndromes; familial adenomatous polyposis (FAP) and Gardner's syndrome (GS); are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein; 2;843 amino acids in length; which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. Functions as a tumor suppressor; promoting rapid degradation of CTNNB1 and is a negative regulator of Wnt signaling. Also plays a role in HGF-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Host:
Mouse
Immunogen:
Recombinant fragment of human APC protein (around aa 1-433)
Isotype:
IgG1
Molecular Weight:
66kDa
Research Area:
Apoptosis; Breast Cancer; Cardiovascular; Colon Cancer; Infectious Disease; Ovarian Cancer; Signal Transduction
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody